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備註請放最後面 違者新聞文章刪除

1.媒體來源:

外媒    sciencealert

2.記者署名:

Carly Cassella

3.完整新聞標題:

Chicago School Kid Discovers New Cancer-Fighting Compound in Bird Poop
Health

芝加哥學童奇蹟般在鳥屎中發現特殊抗癌成分

4.完整新聞內文:

Chicago School Kid Discovers New Cancer-Fighting Compound in Bird Poop
Health

芝加哥學童奇蹟般在鳥屎中發現特殊抗癌成分

05 December 2024
By Carly Cassella

Goose poop. (AHPhotoswpg/Getty Images)

鵝大便(圖庫)

Bringing bird poop to school is usually frowned upon, but middle schoolers in
Chicago are being celebrated as "bonafide biomedical scientists" after one
student delivered some special goose droppings to their science club.

把鳥糞帶到學校通常會被人皺眉，但芝加哥的中學生在一名學生向他們的科學俱樂部送了
一些特殊的鵝糞後，被譽為「真正的生物醫學科學家」。

With the supervision of researchers from the University of Illinois, this
student carefully isolated a bacterium from the goose poop that showed
antibiotic activity.

A natural compound produced by this bacterium is wholly new to science, and
in the lab, it shows cancer-fighting properties.

在伊利諾大學研究人員的監督下，這名學生仔細地從鵝糞便中分離出了一種具有抗生素活
性的細菌。

這種細菌產生的天然化合物對科學來說是全新的，在實驗室中，它顯示出抗癌特性。

Touching bird poop with bare hands is not safe because of all these
pathogens, especially during a national outbreak of bird flu, but in this
particular case, the student was on a mission for science.

They were part of a 14-week educational outreach program to promote
scientific careers with hands-on experience.

由於所有這些病原體，徒手觸摸鳥糞並不安全，尤其是在全國爆發禽流感期間 ，但在這
種特殊情況下，學生肩負著科學使命。

他們是為期 14 週的教育推廣計劃的一部分，旨在透過實踐經驗促進科學職業。

The initiative was designed to involve young learners in the search for new
antibiotics, and as part of the project, students were asked to explore their
neighborhood for new bioactive compounds.

The kids were then taught how to safely grow bacteria and select colonies for
further evaluation by university scientists.

該計劃旨在讓年輕學習者參與尋找新的抗生素，作為該計畫的一部分，學生被要求探索他
們的社區尋找新的生物活性化合物。

然後，孩子們被教導如何安全地培養細菌並選擇菌落以供大學研究生進一步評估。

Middle schoolers learning how to grow and culture bacteria. (Tan et al., ACS
Omega, 2024)

國中生學習如何種植和培養細菌。

The student that brought in the goose feces was able to isolate a species of
gram-negative bacteria, Pseudomonas idahonensis. In the lab, researchers
found this bacterium could inhibit more than 90 percent of the growth of a
gram-positive bacteria species that can cause skin infections.

"Efforts are underway to determine the compound(s) responsible for the
original antibiotic activity observed," the team writes in a published and
peer-reviewed paper on the discovery.

帶回鵝糞便的學生能夠分離出一種革蘭氏陰性細菌，即愛達荷假單胞菌。在實驗室中，研
究人員發現這種細菌可以抑制 90% 以上的會引起皮膚感染的革蘭氏陽性菌的生長。

研究小組在一篇已發表並經過同行評審的關於這一發現的論文中寫道：“正在努力確定導
致觀察到的原始抗生素活性的化合物。”

The middle schooler who found the bird poop is listed as a co-author.

The Pseudomonas bacterium not only showed antibiotic properties, it also
produced a novel natural product, called orfamide N, which has not been seen
by scientists before. Previously discovered orfamides are known to have
useful medical properties, so the team investigated this one further.

發現鳥糞的中學生被列為共同作者。



In the lab, orfamide N slowed the growth of melanoma and ovarian cancer cells.

As dangerous bacteria around the world grow resistant to today's arsenal of
antibiotics, scientists are desperately searching for new medicine, and the
natural world is one of the best places to go searching for antibacterial
compounds.

在實驗室中，orfamide N 減緩了黑色素瘤和卵巢 癌細胞的生長。

隨著世界各地的危險細菌對當今的抗生素庫產生抗藥性，科學家們正在拼命尋找新藥，而
自然界是尋找抗菌化合物的最佳場所之一。

The discovery of natural product antibiotics peaked in the mid-1950s, but
since then, there has been a dangerous decline in this type of drug
development.

Luckily, the natural world is still full of secrets, and some of these
unknowns could help us in our battle against major health issues, such as
bacterial infections and cancer.

天然產物抗生素的發現在 1950 年代中期達到頂峰，但從那時起，此類藥物的開發出現了
危險的衰退。

幸運的是，大自然仍然充滿秘密，其中一些未知因素可以幫助我們對抗細菌感染和癌症等
重大健康問題。

Finding new antibiotics, however, takes years of testing and the failure rate
is high. Out of all 14 environmental samples collected in Chicago, just one
showed evidence of antibiotic activity, and this may not stand up to future
research.

Getting the next generation excited about antibiotic discoveries is a long
game, but scientists at the University of Illinois say their recent success
story just goes to show that "it is possible to integrate educational
outreach programs with high-end natural product discovery."

The study was published in ACS Omega.

然而，尋找新的抗生素需要多年的測試，失敗率很高。在芝加哥收集的所有 14 個環境樣
本中，只有一個顯示出抗生素活性的證據，這可能經不起未來的研究。

讓下一代對抗生素的發現感到興奮是一場漫長的遊戲，但伊利諾大學的科學家表示，他們
最近的成功故事表明「將教育推廣計畫與高端天然產品發現相結合是可能的」。

研究發表在ACS Omega。

5.完整新聞連結 (或短網址)不可用YAHOO、LINE、MSN等轉載媒體:

https://reurl.cc/86pXN7

6.備註:

國外的教育居然可以扎根到這種程度啊...


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※ 作者: STAV72 2024-12-07 15:24:07
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