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此論文發表于美國國家衛生研究所網站：
https://pubmed.ncbi.nlm.nih.gov/33176598/

標題是：
Unexpected detection of SARS-CoV-2 antibodies in the prepandemic period in
Italy
意大利意外檢測到新冠流行前的抗體

研究機構：
國家杜馬里國家醫院基金會，米蘭，意大利
錫耶納大學醫學與外科學院，錫耶納，意大利

摘要：
There are no robust data on the real onset of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection and spread in the prepandemic
period worldwide. We investigated the presence of SARS-CoV-2 receptor-binding
domain (RBD)-specific antibodies in blood samples of 959 asymptomatic
individuals enrolled in a prospective lung cancer screening trial between
September 2019 and March 2020 to track the date of onset, frequency, and
temporal and geographic variations across the Italian regions.
SARS-CoV-2 RBD-specific antibodies were detected in 111 of 959 (11.6%)
individuals, starting from September 2019 (14%), with a cluster of positive
cases (>30%) in the second week of February 2020 and the highest number (53.2%)
in Lombardy. This study shows an unexpected very early circulation of SARS-CoV-
2 among asymptomatic individuals in Italy several months before the first
patient was identified, and clarifies the onset and spread of the coronavirus
disease 2019 (COVID-19) pandemic. Finding SARS-CoV-2 antibodies in asymptomatic
people before the COVID-19 outbreak in Italy may reshape the history of
pandemic.



從2019年9月（14%）開始，959人中有111人（11.6%）檢測到SARS-CoV-2 RBD特異性抗體，
其中在2020年2月的第二周出現了一批陽性病例（>30%），倫巴第地區的陽性率最高
（53.2%）。



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